Analysing Gene Expression Data Using Gaussian Processes

Posted in Science on August 22, 2008

Analysing Gene Expression Data Using Gaussian Processes

Complex gene regulatory mechanisms ensure the proper functioning of biological cells. New high-throughput experimental techniques, such as microarrays, provide a snapshot of gene expression levels of thousands of genes at the same time. If repeated on a sample of synchronized cells, time-series profiles of gene activity can be obtained. The aim is to reconstruct the complex gene regulatory network underlying these profiles. Genes often influence each other in a nonlinear fashion and with intricate interaction patterns. Linear models are often unsuited to capture such relationships. Gaussian processes, on the other hand, are ideal for representing nonlinear relationships. A particular attraction is the automatic relevance determination effect, removing unused inputs and resulting in sparse gene networks.

Author: Lorenz Wernisch, Birkbeck College, University Of London

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