Discriminative Graphical Models for Protein Quaternary Structure Motif Detection

Lecture slides:

• Protein Quaternary Fold Recognition Using Conditional Graphical Models
• Snapshot of Cell Biology
• Example Protein Structures
• Predicting Protein Structures
• Quaternary Folds and Alignments
• Related Work
• Conditional Random Fields
• Our Solution: Conditional Graphical Models
• Linked Segmentation CRF
• Linked Segmentation CRF (II)
• Approximate Inference - Learning
• Approximate Inference - Inference
• Experiments: Target Quaternary Fold
• Features for Protein Fold Recognition
• Experiment Results: Fold Recognition
• Experiment Results: Alignment Prediction
• Experiment Results: Discovery of New Membership Proteins
• Conclusion

Author: Yan Liu, Carnegie Mellon University