Tekzilla Daily Tip #266: Windows: Make Vista Snappier
Vista's file indexing can even make super fast PC's feel slow. So turn it off and speed up Vista's look and feel.
While you're computing away, vista's working hard indexing all your files in the Start menu, user profile folders and files. This is great if you need to do a fast search for a file or folder, but If you have a lot of these files, indexing can make your overall system performance a bit laggy. So turn it off and watch you system fly!